Genomics Core Unit (NIG)
AG Salinas
Welcome to the NGS Integrative Genomics Core Unit (NIG), a scientific, non-profit Next-Generation Sequencing (NGS) facility located at the University Medical Center Göttingen (UMG). The Core Unit is supported by the executive board of the UMG and brings over two decades of expertise in the field of genomics, transcriptomics, and epigenomics. Our primary goal is to actively facilitate and enhance NGS-based research within the biomedical community at both the UMG and the Campus Research Göttingen.
Mission: At NIG, we are dedicated to supporting researchers by providing state-of-the-art Next-Generation Sequencing technologies. We actively participate in the development of new NGS technologies and integrate cutting-edge methodologies into our services for the benefit of our users and research groups.
Collaboration: Formally linked with the Translational Epigenetics Laboratory, led by Prof. Argyris Papantonis, within the Institute of Pathology at UMG, we operate at the forefront of scientific advancements.
CONSULTATION AND CONTACT
We look forward to discussing your specific research project with you. To submit a request, please complete the DNA/RNA sequencing contact form and send it to nig(at)gwdg.de
Datasheet for Sample Submission
Requested analyses will be performed in accordance with the guidelines laid down in the current Nutzerordnung (User Rules and Regulations) and Betriebskonzept (Operational Concept).
We highly recommend to contact us before starting your project. This will allow us to develop the best possible strategy that meets the demands of genome-wide analysis.
Dr. Gabriela Salinas
nig(at)gwdg.de oder gsalina(at)gwdg.de
0551 39-60778
NGS-Integrative Genomics (NIG)
University Medical Center Göttingen (UMG)
Kreuzbergring 57
37075 Göttingen
Sample shipment
NGS-Integrative Genomics (NIG)
University Medical Center Göttingen (UMG)
Kreuzbergring 57
37075 Göttingen
SERVICES
Our comprehensive laboratory services include:
- Initial consultation
- Protocol optimization
- RNA or DNA preparation from whole cells or nuclei fractions
- Quality sample analyses
- Full automated sample library preparation
- Sequencing
- Data pre- and post-processing
- Data quality assessment
- Data storage solutions
NGS-APPLICATIONS
We provide specialized proficiency in a diverse range of DNA/RNA methodologies:
- Stranded mRNA sequencing
- Non-stranded mRNA sequencing
- Stranded total RNA sequencing (WTS)
- Stranded total RNA sequencing for FFPE samples (WTS)
- Stranded mRNA sequencing for very low amount of RNA
- Stranded total RNA sequencing for very low amount of RNA
- Single cell/nuclei RNA sequencing
- miRNA sequencing
- exosome sequencing
- Direct RNA Sequencing using Long Reads technologies
- Epitranscriptomics using native RNA and Long Reads technologies
- PCR-free Whole Genome Sequencing (WGS)
- Nano Whole Genome Sequencing (WGS)
- Single-cell/nuclei DNA sequencing (sc-DNA-Seq)
- Synthetic Long Reads (sLR),
- Whole Exome Sequencing (WES)
- Gene Panels and Metagenomics
- Amplicon sequencing
- Whole methylation bisulfite sequencing
- Methylation-based sequencing methods (using specific antibodies)
- RRBS
- Chip sequencing
- ATAC sequencing
EQUIPMENT
Sequencing
- NovaSeq 6000
- MiSeq
- Oxford Nanopore technologies
Single cell Platforms:
- iCELL8 System
- Chronium 10x genomics
- Visum HD Spatial gene expression
NGS Automation for library preparation:
- Hamilton STAR robotics system
- Magnis NGS Workstation
- Biomek automated Workstation
IT-INFRASTRUCTURE AND BIOINFORMATICS
IT-Infrastructure: The NIG service facility boasts a robust IT infrastructure tailored for high-performance computing (HPC), including dedicated data processing and storage capabilities. Concurrently, we are seamlessly integrated into the High-Performance Computing Center infrastructure in Göttingen, managed by the GWDG (Gesellschaft für wissenschaftliche Datenverarbeitung mbH Göttingen).
To ensure a cost-effective and time-efficient utilization of available resources, The NIG pioneered an automated platform known as the “Virtual Sequencing Analysis Center, -VSAC”. Functioning as a cloud-based genomics data platform, the VSAC is intricately linked to the HPC infrastructure of the GWDG. This platform is designed to streamline, standarize, and operationalize NGS data analysis processes.
Support and Bioinformatics: For all methods, the Core Unit provides extensive statistical and bioinformatics support, guiding researchers from project design conception to the analysis of experimental data. At NIG, we are committed to advancing genomics research, fostering collaboration, and providing tailored solutions to meet the diverse needs of the biomedical research community.
For advanced analyses involving "Second and Third pass data analysis," pre-processed data (following normalization or secondary data analysis) is disseminated to research groups and collaborators with specific expertise. This collaborative approach ensures that refined NGS data undergoes comprehensive evaluation by those equipped to delve into intricate analytical processes. The NIG actively collaborates with various groups situated at the UMG and the Göttingen Research Campus, including the Institute of Medical Bioinformatics (Prof. Dr. Tim Beißbarth, UMG); Biological Systems, Göttingen Campus, Institute for Dynamics of Biological Networks (Prof. Dr. Michael Wibral, University of Göttingen); Dynamics and Biological Physics, Department of Physics (Prof. Dr. Fred Wolf, University of Göttingen); Institute of Medical Informatics (Prof. Dr. Anne-Christin Hauschild, UMG).
COLLABORATIVE GROUPS
In a synergistically collaborative hub-satellite structure, the Core Unit collaborates with research groups at the Campus Göttingen, integrating innovative NGS-based methods. These enhancements serve the needs of both clinical and research projects. Currently we are working on unique methods related to single-cell omics platforms including HD spatial transcriptomics and the introduction of Long Reads approaches on the single-cell level.
RESEARCH FOCUS
Developing novel platforms for single-cell multiomics approaches
We have devised a novel strategy using single-nucleus full-length RNA-sequencing on the iCELL8 instrument. This approach provides a highly sensitive transcriptomic profile encompassing both coding and non-coding RNA molecules, coupled with the identification of variants, including exonic and intronic variants associated with abnormal splicing. The capability to detect intronic variants, even in deep intronic regions, is evident thanks to the enrichment of pre-mRNAs during the processing of the single-nuclei fraction. This is an area that has generally been overlooked in both bulk and single-cell cancer studies. This strategy was applied.
CRU 5002 "Characterization and Targeting of Genome Dynamics for Subtype-Specific Therapy of Pancreatic Cancer"
Central Project CP2: As a part of the DFG-funded Clinical Research Group KFO 5002, the Biomedical Informatics Support Platform (BISP) endeavors through three components i) It aims to develop infrastructure to facilitate the data management of clinical and research data, ii) to implements cutting-edge sequencing methods and iii) to support the consortium with a wide range of bioinformatic pipelines for data analysis. Additionally, the data from the CRU are merged and analyzed within the comprehensive clinical parameters collected in the MolPAC program. In this central project, Next-Generation Sequencing studies and transcriptome analyses are conducted on a central platform for all genome analyses required across the entire consortium, as well as for translational PDAC models established in the Central Project CP1.
Deep learning techniques for association studies of transcriptome and systems dynamics in tissue morphogenesis
In this initiative, scientists from information theory from the Max Planck Institute, theoretical neuroscience, transcriptomics, as well as cell and developmental biology collaborate to, for the first time, combine imaging and expression data to understand the connections between the gene expression of individual cells and the behavior of cell collectives. The goal is to automate the dynamic tissue reconstruction from extensive live imaging data using deep learning for real-time identification of individual cells at key positions in the embryo and their transcriptomic analysis.
The project is funded under the "Big Data in the Life Sciences of the Future" call by the Lower Saxony Ministry of Science and Culture (MWK) and the Volkswagen Foundation.
SFB 1002 "Modulatory Units in Heart Failure"
The Collaborative Research Center (SFB) 1002, funded by the DFG, is dedicated to advancing our understanding of the intricate details and connections associated with the prevalent condition of heart failure. SFB researchers are committed to developing innovative approaches for more effective heart failure treatment. To achieve this goal, they delve into specific signaling pathways governing communication among various cells in the heart, as well as the smallest functional units within heart cells, termed functional microdomains, which play a pivotal role in heart failure development. The NIG's contribution extends beyond the execution of standard NGS protocols to include the analysis of single-cell RNA Sequencing of entire cells, including cardiomyocytes (sized 120-160 µm in diameter) with unique morphology. This involves the implementation of a novel platform that combines the CellenONE and the iCELL8 instruments.
In-situ RNA sequencing with preservation of spatial information
This technique represents an innovative approach enabling the retrieval of information on single-cell transcriptomes or high-multiplex gene expression for the analysis of tissues or clinical samples (biopsies) without requiring tissue dissociation protocols. For spatial transcriptomics applications, the VISUM platform from 10x Genomics is accessible at the Clinic for Neuropathology (AG. Christine Stadelmann-Nesle) at the UMG. Moreover, this method can be seamlessly integrated with single-cell approaches for enhanced analytical capabilities.
Single-cell DNA sequencing combined with synthetic Long Reads
Single-cell DNA-sequencing (sc-DNA-Seq) has not yet made the transition to high-dimensional analysis due to its high cost and the process is itself technically challenging. Nevertheless, this technology is opening new frontiers in complex dieseases e.g., cancer by dissecting the contributions of individual cells, genetic mosaicism, and intra-tumoral genetic heterogeneity in disease development or treatment response. We recently launched a new high-throughput sc-DNA-seq approach using the iCELL8 system and the PicoPlex chemistry from TAKARA that enables precise analysis of Structural Variants and Copy Number Variations (CNVs). Indeed, the combination of synthetic Long Readss (sLR) with sc-DNA technologies provides a state-of-the-art platform in the genomic field allowing the better characterization of tumor heterogeneity and the detection of structural variants, including small aberrations (35 to 100 bp), as well as Copy Number Variations (CNVs) larger than 1 kbp with high precision.
Direct RNA-Seq and Epitranscriptomics using the Oxford Nanopore Technology
The direct RNA sequencing is a new methology that allow the sequence of native RNA (without RT reaction) and simultaneously the investigation of modified bases. After several updates, its sequencing accuracy now exceeds 90%, and the expected number of reads per flow cell is several hundred thousand per flow cell. The read length has also been improved, reaching an N50 read length of over 100 kb.
CORE UNIT MEMBERS
Dr. Gabriela Salinas
Head of Core Unit
E-Mail: gsalina(at)gwdg.de bzw. gabriela.salinas(at)med.uni-goettingen.de
Roya Abbaszadeh
PhD student
roya.abbaszadeh@stud.uni-goettingen.de
Emre Taylan Duman
Bioinformatician
emretaylan.duman(at)med.uni-goettingen.de
Jacqueline Fink
Technical assistant
jacqueline.fink@med.uni-goettingen.de
Fabian Ludewig
Technical assistant
fabian.ludewig(at)med.uni-goettingen.de
Susanne Luthin
Technical assistant
sluthin(at)gwdg.de
Dr. Maren Sitte
Bioinformatician
maren.sitte(at)med.uni-goettingen.de
PUBLICATIONS
2024
dsRNA formation leads to preferential nuclear export and gene expression.
Coban I, Lamping JP, Hirsch AG, Wasilewski S, Shomroni O, Giesbrecht O, Salinas G, Krebber H. Nature. 2024 Jul; 631(8020):432-438. doi: 10.1038/s41586-024-07576-w. Epub 2024 Jun 19. PMID: 38898279 Free PMC article.
KRASG12C-inhibitor-based combination therapies for pancreatic cancer: insights from drug screening.
Tapia Contreras C, Falke JD, Seifert DM, Schneider C, Krauß L, Fang X, Müller D, Demirdizen E, Spitzner M, De Oliveira T, Schneeweis C, Gaedcke J, Kaulfuß S, Mirzakhani K, Wollnik B, Conrads K, Beißbarth T, Salinas G, Hügel J, Beyer N, Rheinländer S, Sax U, Wirth M, Conradi LC, Reichert M, Ellenrieder V, Ströbel P, Ghadimi M, Grade M, Saur D, Hessmann E, Schneider G. Mol Oncol. 2024 Sep 10. doi: 10.1002/1878-0261.13725. Online ahead of print. PMID: 39253995 Free article.
Walkenhorst M, Sonner JK, Meurs N, Engler JB, Bauer S, Winschel I, Woo MS, Raich L, Winkler I, Vieira V, Unger L, Salinas G, Lantz O, Friese MA, Willing A. Nat Commun. 2024 Oct 28;15(1):9287. doi: 10.1038/s41467-024-53657-9. PMID: 39468055 Free PMC article.
PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease.
Schröder S, Fuchs U, Gisa V, Pena T, Krüger DM, Hempel N, Burkhardt S, Salinas G, Schütz AL, Delalle I, Sananbenesi F, Fischer A. Acta Neuropathol. 2024 Aug 29;148(1):32. doi: 10.1007/s00401-024-02787-x. PMID: 39207536 Free PMC article.
Duman ET, Sitte M, Conrads K, Mackay A, Ludewig F, Ströbel P, Ellenrieder V, Hessmann E, Papantonis A, Salinas G.NAR Genom Bioinform. 2024 May 25;6(2):lqae057. doi: 10.1093/nargab/lqae057. eCollection 2024 Jun. PMID: 38800828 Free PMC article.
Liu SF, Kucherenko MM, Sang P, Li Q, Yao J, Nambiar Veetil N, Gransar T, Alesutan I, Voelkl J, Salinas G, Grune J, Simmons S, Knosalla C, Kuebler WM. Eur Respir J. 2024 Nov 14;64(5):2300844. doi: 10.1183/13993003.00844-2023. Print 2024 Nov. PMID: 39542509
Marghany F, Ayobahan SU, Salinas G, Schäfers C, Hollert H, Eilebrecht S. Environ Toxicol Pharmacol. 2024 Jan;105:104348. doi: 10.1016/j.etap.2023.104348. Epub 2023 Dec 20. PMID: 38135202 Free article.
2023
Conche C, Finkelmeier F, Pešić M, Nicolas AM, Böttger TW, Kennel KB, Denk D, Ceteci F, Mohs K, Engel E, Canli Ö, Dabiri Y, Peiffer KH, Zeuzem S, Salinas G, Longerich T, Yang H, Greten FR. Gut. 2023 Sep;72(9):1774-1782. doi: 10.1136/gutjnl-2022-327909. Epub 2023 Jan 27. PMID: 36707233 Free PMC article.
Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration.
Sundaram VK, Schütza V, Schröter NH, Backhaus A, Bilsing A, Joneck L, Seelbach A, Mutschler C, Gomez-Sanchez JA, Schäffner E, Sánchez EE, Akkermann D, Paul C, Schwagarus N, Müller S, Odle A, Childs G, Ewers D, Kungl T, Sitte M, Salinas G, Sereda MW, Nave KA, Schwab MH, Ost M, Arthur-Farraj P, Stassart RM, Fledrich R. Cell Metab. 2023 Dec 5;35(12):2136-2152.e9. doi: 10.1016/j.cmet.2023.10.017. Epub 2023 Nov 20. PMID: 37989315 Free PMC article.
Sabat R, Šimaitė D, Gudjonsson JE, Brembach TC, Witte K, Krause T, Kokolakis G, Bartnik E, Nikolaou C, Rill N, Coulibaly B, Levin C, Herrmann M, Salinas G, Leeuw T, Volk HD, Ghoreschi K, Wolk K. J Allergy Clin Immunol. 2023 Apr;151(4):1015-1026. doi: 10.1016/j.jaci.2022.10.034. Epub 2022 Dec 5. PMID: 36481267
MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration.
Winkler I, Engler JB, Vieira V, Bauer S, Liu YH, Di Liberto G, Grochowska KM, Wagner I, Bier J, Bal LC, Rothammer N, Meurs N, Egervari K, Schattling B, Salinas G, Kreutz MR, Huang YS, Pless O, Merkler D, Friese MA. Sci Adv. 2023 Nov 24;9(47):eadi6855. doi: 10.1126/sciadv.adi6855. Epub 2023 Nov 24. PMID: 38000031 Free PMC article.
HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes.
Grand K, Stoltz M, Rizzo L, Röck R, Kaminski MM, Salinas G, Getwan M, Naert T, Pichler R, Lienkamp SS. J Am Soc Nephrol. 2023 Mar 1;34(3):412-432. doi: 10.1681/ASN.2022010076. Epub 2022 Dec 15. PMID: 36522156 Free article.
Schoger E, Bleckwedel F, Germena G, Rocha C, Tucholla P, Sobitov I, Möbius W, Sitte M, Lenz C, Samak M, Hinkel R, Varga ZV, Giricz Z, Salinas G, Gross JC, Zelarayán LC. Commun Biol. 2023 Jan 21;6(1):79. doi: 10.1038/s42003-022-04402-9. PMID: 36681760 Free PMC article.
Kucherenko MM, Sang P, Yao J, Gransar T, Dhital S, Grune J, Simmons S, Michalick L, Wulsten D, Thiele M, Shomroni O, Hennig F, Yeter R, Solowjowa N, Salinas G, Duda GN, Falk V, Vyavahare NR, Kuebler WM, Knosalla C. Nat Commun. 2023 Jul 21;14(1):4416. doi: 10.1038/s41467-023-39934-z. PMID: 37479718 Free PMC article.
Blood T Helper Memory Cells: A Tool for Studying Skin Inflammation in HS?
Witte K, Schneider-Burrus S, Salinas G, Mössner R, Ghoreschi K, Wolk K, Sabat R. Int J Mol Sci. 2023 May 16;24(10):8854. doi: 10.3390/ijms24108854. PMID: 37240200 Free PMC article.
Surveillance of 3' mRNA cleavage during transcription termination requires CF IB/Hrp1.
Li J, Querl L, Coban I, Salinas G, Krebber H. Nucleic Acids Res. 2023 Sep 8;51(16):8758-8773. doi: 10.1093/nar/gkad530. PMID: 37351636 Free PMC article.
Ayobahan SU, Alvincz J, Reinwald H, Strompen J, Salinas G, Schäfers C, Eilebrecht E, Eilebrecht S. Ecotoxicol Environ Saf. 2023 Jan 15;250:114514. doi: 10.1016/j.ecoenv.2023.114514. Epub 2023 Jan 4. PMID: 36608563 Free article.
Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein AW, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M. iScience. 2023 Aug 30;26(10):107786. doi: 10.1016/j.isci.2023.107786. eCollection 2023 Oct 20. PMID: 37731621 Free PMC article.
Schminke B, Shomroni O, Salinas G, Bremmer F, Kauffmann P, Schliephake H, Oyelami F, Rahat MA, Brockmeyer P. Oral Dis. 2023 Jan;29(1):116-127. doi: 10.1111/odi.13879. Epub 2021 May 5. PMID: 33872434
Müller A, Weyerhäuser P, Berte N, Jonin F, Lyubarskyy B, Sprang B, Kantelhardt SR, Salinas G, Opitz L, Schulz-Schaeffer W, Giese A, Kim EL. Cells. 2023 Apr 30;12(9):1290. doi: 10.3390/cells12091290. PMID: 37174691 Free PMC article.
Hirschhäuser A, Molitor D, Salinas G, Großhans J, Rust K, Bogdan S. Development. 2023 Sep 15;150(18):dev201767. doi: 10.1242/dev.201767. Epub 2023 Sep 27. PMID: 37681301 Free PMC article.
Optimization of Compression and Flexural Properties of Masonry Veneers with Recycled PET-1.
Paredes J, Castillo W, Salinas G, Erazo H, Guerrero VH. Polymers (Basel). 2023 Feb 23;15(5):1122. doi: 10.3390/polym15051122. PMID: 36904362 Free PMC article.
Marghany F, Ayobahan SU, Salinas G, Schäfers C, Hollert H, Eilebrecht S. Environ Toxicol Pharmacol. 2024 Jan;105:104348. doi: 10.1016/j.etap.2023.104348. Epub 2023 Dec 20. PMID: 38135202 Free article.
Wiese M, Pohlmeier B, Kubiak K, El-Khouly FE, Sitte M, Carcaboso AM, Baugh JN, Perwein T, Nussbaumer G, Karremann M, Gielen GH, Salinas G, Kramm CM. J Tradit Complement Med. 2023 Jul 25;14(1):101-108. doi: 10.1016/j.jtcme.2023.07.007. eCollection 2024 Jan. PMID: 38223806 Free PMC article.
Vermeiren S, Cabochette P, Dannawi M, Desiderio S, San José AS, Achouri Y, Kricha S, Sitte M, Salinas-Riester G, Vanhollebeke B, Brunet JF, Bellefroid EJ. iScience. 2023 Oct 31;26(12):108364. doi: 10.1016/j.isci.2023.108364. eCollection 2023 Dec 15. PMID: 38025786 Free PMC article.
2022
Heat stress leads to rapid lipid remodeling and transcriptional adaptations in Nicotiana tabacum pollen tubes
Krawczyk HE, Rotsch AH, Herrfurth C, Scholz P, Shomroni O, Salinas-Riester G, Feussner I, Ischebeck T
Plant Physiol 2022 Jun 1;189(2):490-515. doi: 10.1093/plphys/kiac127.
Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa
Sabat R, Šimaitė D, Gudjonsson JE, Brembach TC, Witte K, Krause T, Kokolakis G, Bartnik E, Nikolaou C, Rill N, Coulibaly B, Levin C, Herrmann M, Salinas G, Leeuw T, Volk HD, Ghoreschi K, Wolk K
J Allergy Clin Immunol 2022 Dec 5:S0091-6749(22)01621-9. doi: 10.1016/j.jaci.2022.10.034. Online ahead of print.
Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy
Shahriyari M, Islam MR, Sakib SM, Rinn M, Rika A, Krüger D, Kaurani L, Gisa V, Winterhoff M, Anandakumar H, Shomroni O, Schmidt M, Salinas G, Unger A, Linke WA, Zschüntzsch J, Schmidt J, Bassel-Duby R, Olson EN, Fischer A, Zimmermann WH, Tiburcy M
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):3106-3121. doi: 10.1002/jcsm.13094. Epub 2022 Oct 18.
Short-Term Test for Toxicogenomic Analysis of Ecotoxic Modes of Action in Lemna minor
Loll A, Reinwald H, Ayobahan SU, Göckener B, Salinas G, Schäfers C, Schlich K, Hamscher G, Eilebrecht S
Environ Sci Technol 2022 Aug 16;56(16):11504-11515. doi: 10.1021/acs.est.2c01777. Epub 2022 Aug 4.
Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors
Latragna A, Sabaté San José A, Tsimpos P, Vermeiren S, Gualdani R, Chakrabarti S, Callejo G, Desiderio S, Shomroni O, Sitte M, Kricha S, Luypaert M, Vanhollebeke B, Laumet G, Salinas G, Smith ESJ, Ris L, Bellefroid EJ
Pain 2022 Aug 1;163(8):e927-e941. doi: 10.1097/j.pain.0000000000002536. Epub 2021 Dec 24.
HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes
Grand K, Stoltz M, Rizzo L, Röck R, Kaminski M, Salinas G, Getwan M, Naert T, Pichler R, Lienkamp S
J Am Soc Nephrol. 2022 Dec 15:ASN.2022010076. doi: 10.1681/ASN.2022010076. Epub ahead of print.
Detailed phenotypic and functional characterization of CMV-associated adaptive NK cells in rhesus macaques
Hasan MZ, Höltermann C, Petersen B, Schrod A, Mätz-Rensing K, Kaul A, Salinas G, Dressel R, Walter L
Front Immunol. 2022 Nov 25;13:1028788. doi: 10.3389/fimmu.2022.1028788.
Small and long RNA transcriptome of whole human cerebrospinal fluid and serum as compared to their extracellular vesicle fractions reveal profound differences in expression patterns and impacts on biological processes
Michel U, Shomroni O, Müller B, Lange P, Salinas G, Bähr M, Koch JC
J Transl Med 2022 Sep 8;20(1):413. doi: 10.1186/s12967-022-03612-3.
Gene-expression profiles of pretreatment biopsies predict complete response of rectal cancer patients to preoperative chemoradiotherapy
Emons G, Auslander N, Jo P, Kitz J, Azizian A, Hu Y, Hess CF, Roedel C, Sax U, Salinas G, Stroebel P, Kramer F, Beissbarth T, Grade M, Ghadimi M, Ruppin E, Ried T, Gaedcke J
Br J Cancer 2022 May 21. doi: 10.1038/s41416-022-01842-2. Online ahead of print.
Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation
Hadadi N, Spiljar M, Steinbach K, Çolakoğlu M, Chevalier C, Salinas G, Merkler D, Trajkovski M.
Elife. 2022 May 17;11:e78556. doi: 10.7554/eLife.78556.
Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure
Lehne F, Pokrant T, Parbin S, Salinas G, Großhans J, Rust K, Faix J, Bogdan S.
Nat Commun 2022 May 6;13(1):2492. doi: 10.1038/s41467-022-30167-0.
IGF-1 Gene Transfer Modifies Inflammatory Environment and Gene Expression in the Caudate-Putamen of Aged Female Rat Brain
Falomir-Lockhart E, Dolcetti FJC, Herrera ML, Pennini J, Zappa Villar MF, Salinas G, Portiansky E, Spittau B, Lacunza E, Hereñú CB, Bellini MJ.
Mol Neurobiol. 2022 Jun;59(6):3337-3352. doi: 10.1007/s12035-022-02791-w. Epub 2022 Mar 19.
Toxicogenomic profiling after sublethal exposure to nerve- and muscle-targeting insecticides reveals cardiac and neuronal developmental effects in zebrafish embryos
Reinwald H, Alvincz J, Salinas G, Schäfers C, Hollert H, Eilebrecht S.
Chemosphere 2022 Mar;291(Pt 1):132746. doi: 10.1016/j.chemosphere.2021.132746.
Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer
Del Campo CV, Liaw NY, Gunadasa-Rohling M, Matthaei M, Braga L, Kennedy T, Salinas G, Voigt N, Giacca M, Zimmermann WH, Riley PR.
Cardiovasc Res. 2022 Jan 29;118(2):597-611. doi: 10.1093/cvr/cvab054.
A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease
Shomroni O, Sitte M, Schmidt J, Parbin S, Ludewig F, Yigit G, Zelarayan LC, Streckfuss-Bömeke K, Wollnik B, Salinas G
Sci Rep. 2022 Mar 8;12(1):4091. doi: 10.1038/s41598-022-07874-1.
Transcriptomic profiling of clobetasol propionate-induced immunosuppression in challenged zebrafish embryos
Essfeld F, Reinwald H, Salinas G, Schäfers C, Eilebrecht E, Eilebrecht S
Ecotoxicol Environ Saf 2022 Mar 15;233:113346. doi: 10.1016/j.ecoenv.2022.113346. Epub 2022 Feb 25.
The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1+ Cells
Jatho A, Zieseniss A, Brechtel-Curth K, Guo J, Böker KO, Salinas G, Wenger RH, Katschinski DM
Cells. 2022 Feb 21;11(4):753. doi: 10.3390/cells11040753.
2021
Transcriptome Analysis of Hypoxic Lymphatic Endothelial Cells Indicates Their Potential to Contribute to Extracellular Matrix Rearrangement
Becker J, Schwoch S, Zelent C, Sitte M, Salinas G, Wilting J
Cells. 2021 Apr 24;10(5).
Protein Signatures of NK Cell-Mediated Melanoma Killing Predict Response to Immunotherapies
Cappello S, Sung HM, Ickes C, Gibhardt CS, Vultur A, Bhat H, Hu Z, Brafford P, Denger A, Stejerean-Todoran I, Köhn RM, Lorenz V, Künzel N, Salinas G, Stanisz H, Legler T, Rehling P, Schön MP, Lang KS, Helms V, Herlyn M, Hoth M, Kummerow C, Bogeski I
Cancer Res 2021 Nov 1;81(21):5540-5554. doi: 10.1158/0008-5472.CAN-21-0164. Epub 2021 Sep 13.
Investigations on the Degradation of the Bile Salt Cholate via the 9,10-Seco-Pathway Reveals the Formation of a Novel Recalcitrant Steroid Compound by a Side Reaction in Sphingobium sp. Strain Chol11
Feller FM, Eilebrecht S, Nedielkov R, Yücel O, Alvincz J, Salinas G, Ludwig KC, Möller H, Philipp B
Microorganisms 2021 Oct 14;9(10):2146. doi: 10.3390/microorganisms9102146.
Screening for potential targets to reduce stenosis in bioprosthetic heart valves
Foth R, Shomroni O, Sigler M, Hörer J, Cleuziou J, Paul T, Eildermann K
Sci Rep. 2021 Jan 28;11(1):2464. doi: 10.1038/s41598-021-81340-2.
Restructuring of the male mice peripheral circadian network after bariatric surgery
Neumann AM, Geißler C, Pilorz V, Olejniczak I, Lewis AG, Seeley RJ, Shomroni O, Salinas-Riester G, Kirchner H, Oster H
J Endocrinol. 2021 Jun 28;250(2):67-79. doi: 10.1530/JOE-20-0611.
Toxicogenomic differentiation of functional responses to fipronil and imidacloprid in Daphnia magna
Pfaff J, Reinwald H, Ayobahan SU, Alvincz J, Göckener B, Shomroni O, Salinas G, Düring RA, Schäfers C, Eilebrecht S
Aquat Toxicol 2021 Jul 27;238:105927. doi: 10.1016/j.aquatox.2021.105927. Online ahead of print.
The Redox Homeostasis of Skeletal Muscle Cells Regulates Stage Differentiation of Toxoplasma gondii
Rahman MT, Swierzy IJ, Downie B, Salinas G, Blume M, McConville MJ, Lüder CGK
Front Cell Infect Microbiol 2021 Nov 22;11:798549. doi: 10.3389/fcimb.2021.798549. eCollection 2021.
Toxicogenomic fin(ger)prints for thyroid disruption AOP refinement and biomarker identification in zebrafish embryos
Reinwald H, König A, Ayobahan SU, Alvincz J, Sipos L, Göckener B, Böhle G, Shomroni O, Hollert H, Salinas G, Schäfers C, Eilebrecht E, Eilebrecht S
Sci Total Environ 2021 Mar 15;760:143914. doi: 10.1016/j.scitotenv.2020.143914. Epub 2020 Dec 10.
Biallelic variants in YRDC cause a developmental disorder with progeroid features
Schmidt J, Goergens J, Pochechueva T, Kotter A, Schwenzer N, Sitte M, Werner G, Altmüller J, Thiele H, Nürnberg P, Isensee J, Li Y, Müller C, Leube B, Reinhardt HC, Hucho T, Salinas G, Helm M, Jachimowicz RD, Wieczorek D, Kohl T, Lehnart SE, Yigit G, Wollnik B
Hum Genet 2021 Sep 20. doi: 10.1007/s00439-021-02347-3. Epub ahead of print.
Differences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons
Sertel SM, Blumenstein W, Mandad S, Shomroni O, Salinas G, Rizzoli SO
Sci Rep 2021 Aug 30;11(1):17374. doi: 10.1038/s41598-021-96846-y.
The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models
Stegmann KM, Dickmanns A, Gerber S, Nikolova V, Klemke L, Manzini V, Schlösser D, Bierwirth C, Freund J, Sitte M, Lugert R, Salinas G, Meister TL, Pfaender S, Görlich D, Wollnik B, Groß U, Dobbelstein M
Virus Res 2021 Jun 3:198469. doi: 10.1016/j.virusres.2021.198469. Epub ahead of print.
CHARGE syndrome and related disorders: A mechanistic link
Ufartes R, Grün R, Salinas G, Sitte M, Kahl F, Wong MTY, van Ravenswaaij-Arts CMA, Pauli S
Hum Mol Genet 2021 Jul 6:ddab183. doi: 10.1093/hmg/ddab183. Epub ahead of print.
Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling
Ulmke PA, Xie Y, Sokpor G, Pham L, Shomroni O, Berulava T, Rosenbusch J, Basu U, Fischer A, Nguyen HP, Staiger JF, Tuoc T
Development. 2021 Feb 8;148(3):dev188276. doi: 10.1242/dev.188276.
Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer
Villa Del Campo C, Liaw NY, Gunadasa-Rohling M, Matthaei M, Braga L, Kennedy T, Salinas G, Voigt N, Giacca M, Zimmermann WH, Riley PR
Cardiovasc Res. 2021 Feb 18:cvab054. doi: 10.1093/cvr/cvab054. Epub ahead of print.
Transmitted resistance in HIV-1 of patients from nine departments of Peru
Yabar CA, Vilcarino GF, Espetia S, Yaya MG, Salinas G, García-Fernández L, Vásquez Becerra RD, Benites C, Santos-Anaya D, Mamani E, Acuña M, Romero S, Cárdenas F
Rev Peru Med Exp Salud Publica 2021 Jan-Mar;38(1):77-82. doi: 10.17843/rpmesp.2021.381.5527. Epub 2021 Jun 25.
EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis
Zink J, Frye M, Frömel T, Carlantoni C, John D, Schreier D, Weigert A, Laban H, Salinas G, Stingl H, Günther L, Popp R, Hu J, Vanhollebeke B, Schmidt H, Acker-Palmer A, Renné T, Fleming I, Benz PM
EMBO Rep 2021 Feb 3;22(2):e48961. doi: 10.15252/embr.201948961. Epub 2021 Jan 29.
2020
SUMOylation controls the neurodevelopmental function of the transcription factor Zbtb20
Ripamonti S, Shomroni O, Rhee JS, Chowdhury K, Jahn O, Hellmann KP, Bonn S, Brose N, Tirard M
J Neurochem 2020 Sep;154(6):647-661. doi: 10.1111/jnc.15008. Epub 2020 Apr 16.
Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction
Michel N, Narayanan P, Shomroni O, Schmidt M
Cell Rep 2020 Jul 21;32(3):107912. doi: 10.1016/j.celrep.2020.107912.
Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes
Pabel S, Reetz F, Dybkova N, Shomroni O, Salinas G, Mustroph J, Hammer KP, Hasenfuss G, Hamdani N, Maier LS, Streckfuss-Bömeke K, Sossalla S
J Mol Med 2020 Oct 9. [Epub ahead of print]
Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models
Marques RF, Engler JB, Küchler K, Jones RA, Lingner T, Salinas G, Gillingwater TH, Friese MA, Duncan KE
Hum Mol Genet 2020 Jul 7:ddaa140. doi: 10.1093/hmg/ddaa140. Online ahead of print.
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity
Koch C, Kuske A, Joosse SA, Yigit G, Sflomos G, Thaler S, Smit DJ, Werner S, Borgmann K, Gärtner S, Mossahebi Mohammadi P, Battista L, Cayrefourcq L, Altmüller J, Salinas-Riester G, Raithatha K, Zibat A, Goy Y, Ott L, Bartkowiak K, Tan TZ, Zhou Q, Speicher MR, Müller V, Gorges TM, Jücker M, Thiery JP, Brisken C, Riethdorf S, Alix-Panabières C, Pantel K.
EMBO Mol Med 2020 Jul 15:e11908. doi: 10.15252/emmm.201911908. Online ahead of print.
Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy
Hanses U, Kleinsorge M, Roos L, Yigit G, Li Y, Barbarics B, El-Battrawy I, Lan H, Tiburcy M, Hindmarsh R, Lenz C, Salinas G, Diecke S, Müller C, Adham I, Altmüller J, Nürnberg P, Paul T, Zimmermann WH, Hasenfuss G, Wollnik B, Cyganek L.
Circulation. 2020 Jul 6. doi: 10.1161/CIRCULATIONAHA.119.044794. Online ahead of print.
DNA Methylation-Mediated Modulation of Endocytosis as Potential Mechanism for Synaptic Function Regulation in Murine Inhibitory Cortical Interneurons
Pensold D, Reichard J, Van Loo KMJ, Ciganok N, Hahn A, Bayer C, Liebmann L, Groß J, Tittelmeier J, Lingner T, Salinas-Riester G, Symmank J, Halfmann C, González-Bermúdez L, Urbach A, Gehrmann J, Costa I, Pieler T, Hübner CA, Vatter H, Kampa B, Becker AJ, Zimmer-Bensch G.
Cereb Cortex 2020 Jun 1;30(7):3921-3937. doi: 10.1093/cercor/bhaa009.
IgG Fc sialylation is regulated during the germinal center reaction upon immunization with different adjuvants
Bartsch YC, Eschweiler S, Leliavski A, Lunding HB, Wagt S, Petry J, Lilienthal GM, Rahmöller J, de Haan N, Hölscher A, Erapaneedi R, Giannou AD, Aly L, Sato R, de Neef LA, Winkler A, Braumann D, Hobusch J, Kuhnigk K, Krémer V, Steinhaus M, Blanchard V, Gemoll T, Habermann JK, Collin M, Salinas G, Manz RA, Fukuyama H, Korn T, Waisman A, Yogev N, Huber S, Rabe B, Rose-John S, Busch H, Berberich-Siebelt F, Hölscher C, Wuhrer M, Ehlers M.
J Allergy Clin Immunol 2020 May 20:S0091-6749(20)30728-4. doi: 10.1016/j.jaci.2020.04.059.
De novo mutations in FBRSL1 cause a novel recognizable malformation and intellectual disability syndrome
Ufartes R, Berger H, Till K, Salinas G, Sturm M, Altmüller J, Nürnberg P, Thiele H, Funke R, Apeshiotis N, Langen H, Wollnik B, Borchers A, Pauli S.
Hum Genet. 2020 May 18.
Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing
Vahsen BF, Ribas VT, Sundermeyer J, Boecker A, Dambeck V, Lenz C, Shomroni O, Caldi Gomes L, Tatenhorst L, Barski E, Roser AE, Michel U, Urlaub H, Salinas G, Bähr M, Koch JC, Lingor P
Cell Death Differ 2020 Apr 27. doi: 10.1038/s41418-020-0543-y. [Epub ahead of print]
Diversity of Clinically Relevant Outcomes Resulting from Hypofractionated Radiation in Human Glioma Stem Cells Mirrors Distinct Patterns of Transcriptomic Changes
Kalasauskas D, Sorokin M, Sprang B, Elmasri A, Viehweg S, Salinas G, Opitz L, Rave-Fraenk M, Schulz-Schaeffer W, Kantelhardt SR, Giese A, Buzdin A, Kim EL
Cancers (Basel) 2020 Mar 1;12(3). pii: E570. doi: 10.3390/cancers12030570.
Ammonium acts systemically while nitrate exerts an additional local effect on Medicago truncatula nodules
Schulze J, Liese R, Ballesteros G, Casieri L, Salinas G, Cabeza RA
Plant Sci. 2020 Mar;292:110383. doi: 10.1016/j.plantsci.2019.110383. Epub 2019 Dec 19.
Increased presence and differential molecular imprinting of transit amplifying cells in psoriasis
Witte K, Jürchott K, Christou D, Hecht J, Salinas G, Krüger U, Klein O, Kokolakis G, Witte-Händel E, Mössner R, Volk HD, Wolk K, Sabat R
J Mol Med 2020 Jan;98(1):111-122. doi: 10.1007/s00109-019-01860-3. Epub 2019 Dec 12.
CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart
Schoger E, Carroll KJ, Iyer LM, McAnally JR, Tan W, Liu N, Noack C, Shomroni O, Salinas G, Groß J, Herzog N, Doroudgar S, Bassel-Duby R, Zimmermann WH, Zelarayán LC
Circ Res. 2020 Jan 3;126(1):6-24. doi: 10.1161/CIRCRESAHA.118.314522. Epub 2019 Nov 15.
2019
Sleep Loss Disrupts Morning-to-Evening Differences in Human White Adipose Tissue Transcriptome
Wilms B, Leineweber EM, Mölle M, Chamorro R, Pommerenke C, Salinas-Riester G, Sina C, Lehnert H, Oster H, Schmid SM.
J Clin Endocrinol Metab. 2019 May 1;104(5):1687-1696.
Nuclear Pre-snRNA Export Is an Essential Quality Assurance Mechanism for Functional Spliceosomes
Becker D, Hirsch AG, Bender L, Lingner T, Salinas G, Krebber H.
Cell Rep. 2019 Jun 11;27(11):3199-3214.e3.
Bassoon proteinopathy drives neurodegeneration in multiple sclerosis
Schattling B, Engler JB, Volkmann C, Rothammer N, Woo MS, Petersen M, Winkler I, Kaufmann M, Rosenkranz SC, Fejtova A, Thomas U, Bose A, Bauer S, Träger S, Miller KK, Brück W, Duncan KE, Salinas G, Soba P, Gundelfinger ED, Merkler D, Friese MA.
Nat Neurosci. 2019 Jun;22(6):887-896.
Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells
Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, Wagner I, Kreutzfeldt M, Di Liberto G, Vincenti I, Lingner T, Salinas G, Brück W, Simons M, Murr R, Kaye J, Zehn D, Pinschewer DD, Merkler D.
Immunity. 2019 Mar 19;50(3):763.
The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction
Witte-Händel E, Wolk K, Tsaousi A, Irmer ML, Mößner R, Shomroni O, Lingner T, Witte K, Kunkel D, Salinas G, Jodl S, Schmidt N, Sterry W, Volk HD, Giamarellos-Bourboulis EJ, Pokrywka A, Döcke WD, Schneider-Burrus S, Sabat R.
J Invest Dermatol. 2019 Jun;139(6):1294-1305.
2018 und früher
IL-12 and IL-15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells
Hydes T, Noll A, Salinas-Riester G, Abuhilal M, Armstrong T, Hamady Z, Primrose J, Takhar A, Walter L, Khakoo SI.
Immun Inflamm Dis. 2018 Mar;6(1):34-46.
PI3K: A master regulator of brain metastasis-promoting macrophages/microglia
Blazquez R, Wlochowitz D, Wolff A, Seitz S, Wachter A, Perera-Bel J, Bleckmann A, Beißbarth T, Salinas G, Riemenschneider MJ, Proescholdt M, Evert M, Utpatel K, Siam L, Schatlo B, Balkenhol M, Stadelmann C, Schildhaus HU, Korf U, Reinz E, Wiemann S, Vollmer E, Schulz M, Ritter U, Hanisch UK, Pukrop T.
Glia. 2018 Nov;66(11):2438-2455.
Immortalization of common marmoset monkey fibroblasts by piggyBac transposition of hTERT
Petkov S, Kahland T, Shomroni O, Lingner T, Salinas G, Fuchs S, Debowski K, Behr R.
PLoS One. 2018 Sep 27;13(9):e0204580. doi: 10.1371/journal.pone.0204580. eCollection 2018.
Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Di Liberto G, Pantelyushin S, Kreutzfeldt M, Page N, Musardo S, Coras R, Steinbach K, Vincenti I, Klimek B, Lingner T, Salinas G, Lin-Marq N, Staszewski O, Costa Jordão MJ, Wagner I, Egervari K, Mack M, Bellone C, Blümcke I, Prinz M, Pinschewer DD, Merkler D.
Cell. 2018 Oct 4;175(2):458-471.e19.
Deep phenotyping of human induced pluripotent stem cell-derived atrial and ventricular cardiomyocytes
Cyganek L, Tiburcy M, Sekeres K, Gerstenberg K, Bohnenberger H, Lenz C, Henze S, Stauske M, Salinas G, Zimmermann WH, Hasenfuss G, Guan K.
JCI Insight. 2018 Jun 21;3(12). pii: 99941.
Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34+ progenitor cells
Herkt SC, Kuvardina ON, Herglotz J, Schneider L, Meyer A, Pommerenke C, Salinas-Riester G, Seifried E, Bonig H, Lausen J.
Haematologica. 2018 Jan;103(1):18-29
Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells
Page N, Klimek B, De Roo M, Steinbach K, Soldati H, Lemeille S, Wagner I, Kreutzfeldt M, Di Liberto G, Vincenti I, Lingner T, Salinas G, Brück W, Simons M, Murr R, Kaye J, Zehn D, Pinschewer DD, Merkler D.
Immunity. 2018 May 15;48(5):937-950.e8.
Epithelial-Mesenchymal Transition during Metastasis of HPV-Negative Pharyngeal Squamous Cell Carcinoma
Ihler F, Gratz R, Wolff HA, Weiss BG, Bertlich M, Kitz J, Salinas G, Rave-Fränk M, Canis M.
Biomed Res Int. 2018 Mar 6;2018:7929104.
Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders
Tomas-Roig J, Piscitelli F, Gil V, Quintana E, Ramió-Torrentà LL, Del Río JA, Moore TP, Agbemenyah H, Salinas G, Pommerenke C, Lorenzen S, Beißbarth T, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U.
CNS Neurosci Ther. 2018 Jun;24(6):528-538.
The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA-Derived Interneurons Fated for the Murine Cerebral Cortex.
Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie BR, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hübner CA, Pieler T, Zimmer G.
Cereb Cortex. 2017 Dec 1;27(12):5696-5714.
Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice
Meyer-Kovac J, Kolbe I, Ehrhardt L, Leliavski A, Husse J, Salinas G, Lingner T, Tsang AH, Barclay JL, Oster H.
Mol Metab. 2017 Mar 29;6(6):512-523.
The adaptation of colorectal cancer cells when forming metastases in the liver: expression of associated genes and pathways in a mouse model
BBocuk D, Wolff A, Krause P, Salinas G, Bleckmann A, Hackl C, Beissbarth T, Koenig S.
BMC Cancer. 2017 May 19;17(1):342.
The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner
Wiese M, Walther N, Diederichs C, Schill F, Monecke S, Salinas G, Sturm D, Pfister SM, Dressel R, Johnsen SA, Kramm CM.
Oncotarget. 2017 Apr 18;8(16):27300-27313.
Histone deacetylase inhibitor MS-275 augments expression of a subset of IFN-γ-regulated genes in Toxoplasma gondii-infected macrophages but does not improve parasite control
Sumpf K, Nast R, Downie B, Salinas G, Lüder CG.
Exp Parasitol. 2017 Feb 9. pii: S0014-4894(17)30083-8.
mRNA quality control is bypassed for immediate export of stress-responsive transcripts
Zander G, Hackmann A, Bender L, Becker D, Lingner T, Salinas G, Krebber H.
Nature. 2016 Dec 12.
The functional readthrough extension of malate dehydrogenase reveals a modification of the genetic code
Hofhuis J, Schueren F, Nötzel C, Lingner T, Gärtner J, Jahn O, Thoms S.
Open Biol. 2016 Nov;6(11).
Pre-Infection Transcript Levels of FAM26F in PBMCS Inform about Overall Plasma Viral Load in Acute and Postacute Phase after SIV-Infection
Javed A, Leuchte N, Salinas G, Opitz L, Stahl-Hennig C, Sopper S, Sauermann U.
J Gen Virol. 2016 Oct 18.
Identification of New Fungal Peroxisomal Matrix Proteins and Revision of the PTS1 Consensus
Nötzel C, Lingner T, Klingenberg H, Thoms S.
Traffic. 2016 Oct;17(10):1110-24
Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation
Ufer F, Vargas P, Engler JB, Tintelnot J, Schattling B, Winkler H, Bauer S, Kursawe N, Willing A, Keminer O, Ohana O, Salinas-Riester G, Pless O, Kuhl D, Friese MA.
Sci Immunol. 2016 Sep 23;1(3):eaaf8665.
Treatment of prostate cancer cells with S-adenosylmethionine leads to genome-wide alterations in transcription profiles
Schmidt T, Leha A, Salinas-Riester G.
Gene. 2016 Sep 26. pii: S0378 1119(16)30770-3
The SCN Clock Governs Circadian Transcription Rhythms in Murine Epididymal White Adipose Tissue
Kolbe I, Husse J, Salinas G, Lingner T, Astiz M, Oster H.
J Biol Rhythms. 2016 Sep 20. pii: 0748730416666170
Effects of Long-Term Environmental Enrichment on Anxiety, Memory, Hippocampal Plasticity and Overall Brain Gene Expression in C57BL6 Mice
Hüttenrauch M, Salinas G, Wirths O.
Front Mol Neurosci. 2016 Aug 3;9:62
Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer
Azizian A, Epping I, Kramer F, Jo P, Bernhardt M, Kitz J, Salinas G, Wolff HA, Grade M, Beißbarth T, Ghadimi BM, Gaedcke J.
Int J Mol Sci. 2016 Apr 15;17(4):568
The transcriptomes of novel marmoset monkey embryonic stem cell lines reflect distinct genomic features
Debowski K, Drummer C, Lentes J, Cors M, Dressel R, Lingner T, Salinas-Riester G, Fuchs S, Sasaki E, Behr R.
Sci Rep. 2016 Jul 7;6:29122
Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model
Hüttenrauch M, Brauß A, Kurdakova A, Borgers H, Klinker F, Liebetanz D, Salinas-Riester G, Wiltfang J, Klafki HW, Wirths O.
Transl Psychiatry. 2016 May 3;6:e800
MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO
DKohrs N, Kolodziej S, Kuvardina ON, Herglotz J, Yillah J, Herkt S, Piechatzek A, Salinas Riester G, Lingner T, Wichmann C, Bonig H, Seifried E, Platzbecker U, Medyouf H, Grez M, Lausen J.
PLoS Genet. 2016 Mar 18;12(3):e1005946
The Cannabinoid CB1/CB2 Agonist WIN55212.2 Promotes Oligodendrocyte Differentiation In Vitro and Neuroprotection During the Cuprizone-Induced Central Nervous System Demyelination
Tomas-Roig J, Wirths O, Salinas-Riester G, Havemann-Reinecke U.
CNS Neurosci Ther. 2016 May; 22(5):387-95
Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice
Tomas-Roig J, Piscitelli F, Gil V, Del Río JA, Moore TP, Agbemenyah H, Salinas-Riester G, Pommerenke C, Lorenzen S, Beißbarth T, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U.
Behav Brain Res. 2016 Apr 15;303:34-43
Short-Term Molecular Acclimation Processes of Legume Nodules to Increased External Oxygen Concentration
Avenhaus U, Cabeza RA, Liese R, Lingner A, Dittert K, Salinas-Riester G, Pommerenke C, Schulze J.
Front Plant Sci. 2016 Jan 6;6:1133. doi: 10.3389/fpls.2015.01133. eCollection 2015
CD14 is a key organizer of microglial responses to CNS infection and injury
Janova H, Böttcher C, Holtman IR, Regen T, van Rossum D, Götz A, Ernst AS, Fritsche C, Gertig U, Saiepour N, Gronke K, Wrzos C, Ribes S, Rolfes S, Weinstein J, Ehrenreich H, Pukrop T, Kopatz J, Stadelmann C, Salinas-Riester G, Weber MS, Prinz M, Brück W, Eggen BJ, Boddeke HW, Priller J, Hanisch UK.
Glia. 2016 Apr;64(4):635-49
Long-Term Oocyte-Like Cell Development in Cultures Derived from Neonatal Marmoset Monkey Ovary
Fereydouni B, Salinas-Riester G, Heistermann M, Dressel R, Lewerich L, Drummer C, Behr R.
Stem Cells Int. 2016;2016:2480298
Modulation of CNS autoimmune responses by CD8(+) T cells coincides with their oligoclonal expansion
Fischer HJ, van den Brandt J, Lingner T, Odoardi F, Flügel A, Weishaupt A, Reichardt HM.
J Neuroimmunol. 2016 Jan 15;290:26-32
Microarray analysis of circulating micro RNAs in the serum of patients with polymyositis and dermatomyositis reveals a distinct disease expression profile and is associated with disease activity
Misunova M, Salinas-Riester G, Luthin S, Pommerenke C, Husakova M, Zavada J, Klein M, Plestilova L, Svitalkova T, Cepek P, Novota P, Vencovsky J.
Clin Exp Rheumatol. 2016 Jan-Feb;34(1):17-24. Epub 2015 Nov 17
SMRT sequencing of the Campylobacter coli BfR-CA-9557 genome sequence reveals unique methylation motifs
Zautner AE, Goldschmidt AM, Thürmer A, Schuldes J, Bader O, Lugert R, Groß U, Stingl K, Salinas G, Lingner T.
BMC Genomics. 2015 Dec 21;16:1088
Global analysis of asymmetric RNA enrichment in oocytes reveals low conservation between closely related Xenopus species
Claußen M, Lingner T, Pommerenke C, Opitz L, Salinas G, Pieler T.
Mol Biol Cell. 2015 Nov 1;26(21):3777-87
Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage
Linker RA, Lee DH, Flach AC, Litke T, van den Brandt J, Reichardt HM, Lingner T, Bommhardt U, Sendtner M, Gold R, Flügel A, Lühder F.
Eur J Immunol. 2015 May;45(5):1326-38
Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions
Planas R, Metz I, Ortiz Y, Vilarrasa N, Jelčić I, Salinas-Riester G, Heesen C, Brück W, Martin R, Sospedra M.
Ann Clin Transl Neurol. 2015 Sep;2(9):875-93
Influence of total genomic alteration and chromosomal fragmentation on response to a combination of azacitidine and lenalidomide in a cohort of patients with very high risk MDS
Ganster C, Shirneshan K, Salinas-Riester G, Braulke F, Schanz J, Platzbecker U, Haase D.
Leuk Res. 2015 Oct;39(10):1079-87
Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator
Chang Liao ML, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S, Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH.
Circ Res. 2015 Aug 14;117(5):401-12
Next generation sequencing of sex-specific genes in the livers of obese ZSF1 rats
Babelova A, Burckhardt BC, Salinas-Riester G, Pommerenke C, Burckhardt G, Henjakovic M.
Genomics. 2015 Jul 19. pii: S0888-7543(15) 30021-5
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells
Liefke R, Windhof-Jaidhauser IM, Gaedcke J, Salinas-Riester G, Wu F, Ghadimi M, Dango S.
Genome Med. 2015 Jun 30;7(1):66
Thymocyte-derived BDNF influences T-cell maturation at the DN3/DN4 transition stage
Linker RA, Lee DH, Flach AC, Litke T, van den Brandt J, Reichardt HM, Lingner T, Bommhardt U, Sendtner M, Gold R, Flügel A, Lühder F.
Eur J Immunol. 2015 May;45(5):1326-38
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